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KMID : 0854720070270030176
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Korean Journal of Asthma, Allergy and Clinical Immunology
2007 Volume.27 No. 3 p.176 ~ p.180
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Prevalence of Subclinical Aspirin-Intolerant Asthma in Patients with Nasal Polyposis and Chronic Rhinosinusitis
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Park Ji-Won
Kim Seok-Hwa
Min Sun-Yang
Seo Beum-Suk
Chung Duk-Hee
Choi Jeong-Hee
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Abstract
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Background and objective: Aspirin-intolerant asthma (AIA) is a distinct clinical syndrome characterized by aspirin sensitivity, asthma, and nasal polyposis (NP). The incidence of AIA in adult asthmatics is 8~20%, and the prevalence of AIA among adult asthmatics with NP and/or chronic rhinosinusitis further increases to 30~40%. However, the prevalence of subclinical AIA in patients with NP and/or chronic rhinosinusitis has rarely been investigated.
Method: A total of 36 patients with NP and chronic rhinosinusitis who was scheduled for polypectomy were enrolled. All had no previous history of AIA. Lysine-aspirin bronchoprovocation tests were performed on all subjects before operation. Positive response was defined as a >15% fall in FEV1 from baseline.
Result: Five of 36 patients (13.8%) showed positive responses to lysine-aspirin provocation tests (4 subject with NP+asthma and 1 with NP alone, P<0.05). There was a significant difference in the PC20 to methacholine between AIA+NP and NP+asthma groups (0.22+/-0.37 vs. 3.13+/-2.70 mg/mg, P<0.05), and peripheral blood eosinophil counts tended to increase from NP alone through NP+asthma to AIA+NP group (P<0.01).
Conclusion: The prevalence of subclinical AIA in patients with NP and chronic rhinosinusitis was 13.8%, and AIA was especially more prevalent in the asthmatics with NP and chronic rhinosinusitis.
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KEYWORD
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Nasal polyposis, Chronic rhinosinusitis, Aspirin-intolerant asthma
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